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Updated: May 16, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
Published on: May 22, 2014
ZNFX1: a multifunctional modulator of the innate immune response
Li Yi Cheng1, Roy Parker1,2
1Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States.
Abstract:
Recent research has identified ZNFX1 as a critical modulator of the innate immune response. Individuals with loss of function mutations in ZNFX1 have chronic inflammation and increased susceptibility to various pathogens. Several potential functions of ZNFX1 have been proposed, including binding double-stranded RNA to activate antiviral innate immunity, inhibiting the NLRP3 inflammasome, and regulating the stability of host mRNAs. Notably, homologs of ZNFX1 are implicated in innate immunity across a wide range of species, including contributing to transgenerational epigenetic inheritance of small RNA-based defense in C. elegans. In this review, we discuss the significance of ZNFX1 and explore the potential underlying mechanisms that govern its diverse functions.
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