Recurrent Ileocolic Intussusception in Children: A Scoping Review
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Updated: May 16, 2025

Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Salvatore Arena1, Fabiola Cassaro1, Giulia Maisano1
1Department of Human Pathology of Adult and Childhood "Gaetano Barresi", University of Messina, Messina, Italy.
Insights
Recurrent intussusception in children is common, with over 85% successfully managed non-surgically. Surgery for recurrent intussusception is reserved for suspected pathological leading points or multiple episodes.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Clinical Research
Background:
- Intussusception is the leading cause of intestinal obstruction in children.
- Recurrent intussusception (RI) lacks a validated treatment algorithm.
- Optimal management strategies for pediatric RI require further definition.
Purpose of the Study:
- To evaluate the incidence of recurrent intussusception (RI) in children.
- To determine surgical intervention and pathological leading point (PLP) rates in RI.
- To define the most appropriate management for pediatric RI.
Main Methods:
- Systematic literature review of English-written pediatric intussusception studies.
- Inclusion criteria excluded case reports, adult/mixed cases, specific intussusception types, and meta-analyses.
- Data extraction focused on RI incidence, non-surgical reduction attempts, surgical rates, and PLP identification.
Main Results:
- 23 articles analyzed 26,731 intussusception cases, including 3164 (11.8%) with recurrence.
- Median of 5 non-surgical reduction attempts were reported for RI.
- 12.1% of RI patients underwent surgery, with a 3.95% overall PLP rate.
Conclusions:
- Pathological leading points (PLPs) are infrequently found and not clearly associated with intussusception recurrence.
- Over 85% of recurrent intussusception cases achieve successful non-surgical management.
- Pediatric recurrent intussusception management mirrors primary cases; surgery is indicated for suspected PLP or persistent recurrence after discussion with parents.
Abstract:
Background: Intussusception is the most common cause of acute intestinal obstruction in children. It can be initial idiopathic intussusception or a recurrent intussusception (RI), and in this latter case, there is not a validated algorithm for optimal treatment. The aim of the study is to review the international literature to evaluate the incidence of RI, to determine the rates of surgical intervention and pathological leading point (PLP), and to define the most appropriate management for children with RI. We included English-written papers with pediatric population, excluding case reports, papers with adult or mixed cases, studies focusing on ileo-ileal or colo-colic intussusception, meta-analysis studies, or papers with unclear or replaced data. Results: A total number of 23 articles were included for a total of 26,731 patients affected by intussusception and 3164 recurrent patients (11.8%). The number of attempts of nonsurgical reduction ranged from 3 to 10 (median 5). On 2965 RI, 358 underwent surgery (12.1%). A pathologic leading point was found in 99 patients (3.95%). Conclusions: The presence of a PLP does not seem to be associated with the recurrence of intussusception. More than 85% of RI underwent successful nonsurgical management. RI should be safely approached in the same way as primary intussusception, and surgery should be reserved to cases where a PLP has been suspected. In cases of multiple episodes, surgery can be considered an effective way to avoid recurrences, and this possibility should be discussed with parents.
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