Association between neutrophil-to-lymphocyte ratio and all-cause and cardiovascular mortality among adults with cancer from NHANES 2005-2018: a retrospective cohort study
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View abstract on PubMed
Summary
This summary is machine-generated.Elevated neutrophil-to-lymphocyte ratio (NLR) is associated with increased risks of all-cause and cardiovascular disease (CVD) mortality in cancer patients. This finding highlights NLR as a potential prognostic biomarker in oncology care.
Area Of Science
- Oncology
- Cardiovascular Medicine
- Hematology
Background
- Limited evidence exists on the association between neutrophil-to-lymphocyte ratio (NLR) and mortality in cancer patients.
- Neutrophil-to-lymphocyte ratio (NLR) is an inflammatory marker that may predict outcomes in various diseases.
Purpose Of The Study
- To investigate the relationship between NLR and all-cause and cardiovascular disease (CVD) mortality in adults with cancer.
- To assess NLR as a prognostic indicator for mortality in a cancer patient cohort.
Main Methods
- Retrospective cohort study of 2,639 cancer patients from the U.S. NHANES dataset (2005-2018).
- Analysis included demographic, laboratory, and mortality data.
- Multivariable Cox regression, subgroup, and restricted cubic spline analyses were employed to evaluate associations between NLR and mortality outcomes.
Main Results
- A high NLR, analyzed as a continuous variable, was significantly correlated with increased all-cause mortality (HR, 1.09; 95% CI, 1.05-1.12) and CVD mortality (HR, 1.12; 95% CI, 1.05-1.19).
- When assessed categorically, higher NLR quartiles showed a dose-response relationship with increased all-cause and CVD mortality.
- Kaplan-Meier analysis revealed lower survival rates with higher NLR, and restricted cubic spline analysis indicated a positive linear association between NLR and mortality.
Conclusions
- Elevated NLR is significantly associated with higher risks of all-cause and CVD mortality in adults with cancer.
- NLR may serve as a valuable prognostic biomarker for predicting mortality in cancer patients.
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