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Related Experiment Video

Updated: May 16, 2025

Microbubble Fabrication of Concave-porosity PDMS Beads
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PDMS biointerfaces featuring honeycomb-like well microtextures designed for a pro-healing environment.

Andreea Mariana Negrescu1,2, Simona Nistorescu1,3, Anca Bonciu3

  • 1Faculty of Biology, University of Bucharest Splaiul Independenţei 91-95 050095 Bucharest Romania anisoara.cimpean@bio.unibuc.ro.

RSC Advances
|April 2, 2025
PubMed
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A novel honeycomb-textured silicone surface reduces the foreign body response (FBR) in breast implants. This microstructured biointerface improves fibroblast behavior and limits inflammatory reactions and bacterial colonization for better implant integration.

Area of Science:

  • Biomaterials Science
  • Plastic Surgery
  • Tissue Engineering

Background:

  • Modulating the foreign body response (FBR) is crucial for reducing breast implant complications and improving performance.
  • Current methods for patterning polydimethylsiloxane (PDMS) on large-scale biointerfaces are challenging.
  • Tailoring material properties to influence FBR is a key strategy in implantology.

Purpose of the Study:

  • To design and fabricate a large-scale, honeycomb-like well biointerface using PDMS.
  • To investigate the effectiveness of this microstructured surface in modulating the FBR.
  • To create a pro-healing environment for prosthetic interfaces.

Main Methods:

  • A honeycomb-like well biointerface was replicated in PDMS at a large scale.

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  • Grayscale masks assisted laser-based 3D texturing was used to create polycarbonate molds.
  • Fibroblast and macrophage responses, as well as microbial colonization, were assessed on smooth versus microstructured surfaces.

    • Main Results:

    • The honeycomb topography altered fibroblast adhesion and morphology compared to smooth surfaces.
    • The microstructured surface reduced the inflammatory response of macrophages.
    • Macrophage fusion was inhibited, significantly limiting both Gram-positive and Gram-negative bacterial colonization.

    Conclusions:

    • A honeycomb-inspired topography on PDMS surfaces can effectively mitigate the in vitro foreign body response to silicone implants.
    • This innovative approach offers a promising strategy for enhancing the integration and performance of prosthetic interfaces.
    • The microstructured surface promotes a pro-healing environment and reduces the risk of implant-associated infections.