Computational approaches for identifying neuropeptides: A comprehensive review

Neuropeptides (NPs) are key signaling molecules that interact with G protein-coupled receptors, influencing neuronal activities and developmental pathways, as well as the endocrine and immune systems. They are significant in disease contexts, offering potential therapeutic targets for conditions such as anxiety, neurological disorders, cardiovascular health, and diabetes. Understanding and detecting NPs is crucial because of their complex functions in health and disease. Historically, identifying NPs via wet lab techniques has been time-consuming and costly. However, integrating computational methods has shown the potential to improve efficiency, accuracy, and cost-effectiveness. Computational techniques, such as artificial intelligence and machine learning, have been extensively researched in recent years for the identification of NP. This review explores the application of machine learning (ML) techniques in predicting various aspects of NPs, including their sequences, cleavage sites, and precursors. Additionally, it provides insights into databases containing NP metadata and specialized tools used in this domain.