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Related Experiment Video

Updated: May 16, 2025

Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats
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Hydrogel Adhesive Integrated-Microstructured Electrodes for Cuff-Free, Less-Invasive, and Stable Interface for Vagus

Jae Young Park1,2,3, Jongcheon Lim1,2,3, Carl R Russell1

  • 1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.

Advanced Healthcare Materials
|April 2, 2025
PubMed
Summary

This study presents a new, less invasive hydrogel microdevice for vagus nerve stimulation (VNS). The cuff-free design reduces surgical risks associated with traditional VNS implantation.

Keywords:
hydrogel adhesivemedical deviceneural interfaceneural stimulationvagus nerve stimulation

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Materials Science

Background:

  • Vagus nerve stimulation (VNS) is a key treatment for neurological disorders.
  • Current VNS implantation involves surgical risks like nerve or vascular damage due to nerve isolation and cuffing.

Purpose of the Study:

  • To develop a novel, less invasive, cuff-free microdevice for vagus nerve interfacing.
  • To minimize surgical risks associated with VNS implantation.

Main Methods:

  • A stretchable microdevice with a novel hydrogel adhesive was designed.
  • Kirigami structures were incorporated to ensure uniform tissue contact and accommodate hydrogel hydration changes.
  • Device adhesion and functionality were tested on a rodent vagus nerve model in physiological fluid.

Main Results:

  • The device demonstrated robust adhesion to the vagus nerve without isolation or cuffing.
  • Stable and clear evoked compound action potentials (~1500 µV) were recorded from C-fibers at 0.4 mA.
  • The hydrogel adhesive successfully crosslinked on biological tissue.

Conclusions:

  • The developed hydrogel adhesive-integrated microdevice offers a safer, cuff-free alternative for vagus nerve interfacing.
  • This innovative platform reduces risks during VNS implantation by avoiding nerve isolation.
  • The technology shows promise for interfacing with delicate neural and vascular structures.