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Related Concept Videos

Disturbances in Heart Rhythm01:28

Disturbances in Heart Rhythm

737
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
737

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Standardized endpoint definitions for trials of transcatheter left atrial appendage closure: a consensus from the Left Atrial Appendage Academic Research Consortium†.

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Pulsed Field or Cryoballoon Ablation for Paroxysmal Atrial Fibrillation - insights from acute and chronic electroanatomic remapping in the randomized SINGLE-SHOT CHAMPION trial.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
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Autonomic effects and ablation success after pulsed field and cryoballoon ablation: a SINGLE SHOT CHAMPION substudy.

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Early complications and long-term outcome of patients treated with a Subcutaneous Cardioverter-Defibrillator: temporal trends and clinical implications of the anesthetic strategies adopted at implant.

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Safety and Feasibility of Pulsed Field Ablation With a Pentaspline Catheter in Patients With Extravascular ICD.

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Related Experiment Video

Updated: May 16, 2025

Robotic Ablation of Atrial Fibrillation
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Pulsed-Field Ablation for Persistent Atrial Fibrillation in EU-PORIA Registry.

Jun Hirokami1, Kyoung Ryul Julian Chun1, Stefano Bordignon1

  • 1Cardioangiologisches Centrum Bethanien, Frankfurt, Germany.

Journal of Cardiovascular Electrophysiology
|April 2, 2025
PubMed
Summary

Pulsed-field ablation (PFA) for persistent atrial fibrillation (AF) showed that pulmonary vein isolation (PVI) alone was more effective than PVI plus additional ablation, with fewer atrial tachycardia recurrences.

Keywords:
atrial fibrillationextra pulmonary vein ablationpersistent AFpropensity score matchingpulmonary vein isolationpulsed‐field ablation

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Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Devices

Background:

  • Limited real-world data exists on the efficacy and safety of pulsed-field ablation (PFA) in symptomatic atrial fibrillation (AF) patients.
  • PFA utilizes a pentaspline multi-electrode catheter for cardiac procedures.

Purpose of the Study:

  • To assess the efficacy and safety of PFA in patients diagnosed with persistent AF.
  • To compare outcomes between pulmonary vein isolation (PVI) alone versus PVI with additional ablation strategies.

Main Methods:

  • A registry-based study collected data from seven European centers on early commercial PFA use.
  • Patients were divided into two groups: PVI only and PVI plus extra pulmonary vein (PV) ablation.
  • Procedural and 1-year follow-up data were analyzed.

Main Results:

  • The study included 448 patients (347 PVI only, 101 PVI + additional ablation).
  • The PVI only group had significantly fewer atrial tachyarrhythmia recurrences (69% vs. 56%, p=0.013) and atrial tachycardia recurrences (8% vs. 22%, p<0.001) at 1 year.
  • No significant difference was observed in AF recurrence (25% vs. 28%, p=0.713) or major complications (2.0% vs. 1.0%, p=0.345).

Conclusions:

  • PVI combined with extra PV ablation using a pentaspline PFA catheter is linked to a higher rate of atrial tachycardia recurrence.
  • For persistent AF, a strategy involving only PVI may offer superior effectiveness.
  • Simpler PFA approaches warrant further investigation for persistent AF management.