Cartilage Lubrication from the Perspective of Wettability

Cartilage exhibits an extremely low friction and very low wearability within the liquid environment of the joint. It is also capable of switching wettability between superhydrophilicity and hydrophobicity in both wetting and dry conditions (specific experimental operations or open wounds). Therefore, the understanding of cartilage lubrication from the perspective of wettability provides inspiration for the design of artificial cartilage and sections with motion of soft actuators with extremely low coefficients of friction (COF). In this review, the lubrication of articular cartilage is introduced and discussed from the view of wettability. First, basic principles of articular cartilage lubrication and wettability are described with a focus on compositions and wettability of articular cartilage, and in particular the relationship between the phospholipid layers and wettability on articular cartilage, and the supramolecular synergy of synovial fluid on the lubrication of articular cartilage. Subsequently, the wettability and lubrication of articular cartilage under different stimuli (such as shear, pH, temperature, and electric field) is introduced for insights into cartilage lubrication. Finally, we present a comprehensive summary and delineate the challenges within the domain of cartilage lubrication and wettability for assisting researchers in formulating viable concepts for the design of efficient cartilage substitution or smart soft lubricating devices.