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Related Concept Videos

Esophageal Perforation-I: Introduction01:22

Esophageal Perforation-I: Introduction

52
Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
52
Thoracic Aorta01:15

Thoracic Aorta

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The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
294

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Updated: May 16, 2025

A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury
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Rheumatoid Inflammation Causing Aortic Valve Perforation.

Neeta Bachani1, Rashmi Rao1, Neha Arora1

  • 1Holy Family Hospital, Mumbai, India.

Echocardiography (Mount Kisco, N.Y.)
|April 2, 2025
PubMed
Summary
This summary is machine-generated.

Rheumatoid arthritis can cause severe aortic regurgitation due to leaflet perforation. Surgical aortic valve replacement confirmed rheumatoid etiology through characteristic palisading granulomas in valve histology.

Keywords:
aortic regurgitationendocarditisvalvular heart disease

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Area of Science:

  • Cardiology
  • Rheumatology
  • Pathology

Background:

  • Rheumatoid arthritis (RA) is a systemic autoimmune disease primarily affecting joints.
  • Cardiac manifestations of RA, though less common, can be severe and impact prognosis.
  • Aortic valve involvement in RA typically presents as valvulitis leading to regurgitation.

Observation:

  • An elderly female patient with a history of RA presented with worsening shortness of breath.
  • Transesophageal echocardiography identified severe aortic regurgitation.
  • The echocardiogram revealed perforation of the non-coronary and left coronary aortic leaflets.

Findings:

  • The patient underwent aortic valve replacement after clinical stabilization and antibiotic treatment.
  • Histopathological examination of the explanted aortic valve demonstrated the presence of palisading granulomas.
  • These histological findings are pathognomonic for rheumatoid etiology.

Implications:

  • This case highlights a rare but serious cardiac complication of rheumatoid arthritis.
  • Early recognition and management of RA-associated aortic valve disease are crucial.
  • Histopathology remains essential for confirming the etiology of valvular heart disease in RA patients.