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Updated: May 16, 2025
Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
Outcome measures reported by cancer patients treated with tyrosine kinase inhibitors: a methodological study
Ana Maria Teixeira Pires1, Julie Ann Ponto2, Eliana Cavalari Teraoka1
1Universidade Federal de São Paulo. São Paulo, São Paulo, Brazil.
Objectives:
to validate the content of an outcome measurement instrument with expert judges and to assess the understandability and suitability of this validated instrument with cancer patients undergoing tyrosine kinase inhibitor (TKI) therapy.
Methods:
a methodological study, which included the development of an instrument through integrative review, content validity, using the Delphi technique with expert judges, and pilot testing, to verify users' understandability and suitability to the instrument.
Results:
literature review allowed constructing PRO-CTCAE® Estudo PROM-TKI Brasil, with 16 items, which was later submitted to validity using the Delphi technique. After the second round, the final instrument consisted of 20 items, with a Content Validity Index (CVI) of 0.878. The pilot test showed that the instrument is understandable and suitable for the target population (CVI of 1.0).
Conclusions:
PRO-CTCAE® Estudo PROM-TKI Brasil obtained evidence of validity for use during TKI therapy.
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