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Feedback Regulation of Calcium Concentration

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...

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Related Experiment Video

Updated: May 16, 2025

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

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Modeling traveling calcium waves in cellular structures.

Patrick A Shoemaker¹, Bo M B Bekkouche^2,3

¹Computational Science Research Center, San Diego State University, San Diego, CA, USA. pshoemaker@sdsu.edu.

Journal of Computational Neuroscience

|April 2, 2025

Summary

This summary is machine-generated.

Calcium waves in cellular structures propagate regeneratively, with speeds up to hundreds of micrometers per second. Ryanodine receptors significantly influence wave characteristics, especially in dendrite-like processes.

Keywords:

Astrocytes Calcium waves Cellular processes Intracellular calcium Neurons Traveling waves

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Last Updated: May 16, 2025

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Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients

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Published on: July 16, 2018

Area of Science:

Cellular dynamics
Computational neuroscience
Biophysics

Background:

Calcium waves are crucial for cellular signaling and spatiotemporal processing.
Understanding the parameters governing calcium wave propagation is essential for deciphering cellular functions.

Purpose of the Study:

To investigate the parametric dependence of traveling calcium waves in cellular structures.
To elucidate how anatomical and physiological factors influence wave characteristics like speed and amplitude.

Main Methods:

Parametric simulation study of traveling calcium waves.
Modeling inositol trisphosphate and ryanodine receptors.
Analysis of wave propagation in dendrite-like processes and cell bodies.

Main Results:

Calcium waves are fully regenerative across a range of parameters.
Hopf bifurcations lead to periodic calcium spikes in unstable regimes.
Wave speeds range from tens to hundreds of micrometers per second, influenced by receptor presence and density.

Conclusions:

Ryanodine receptors significantly enhance calcium wave speed and amplitude.
Receptor density and calcium diffusion are key determinants of wave characteristics.
Simulations reveal the complex dynamics of calcium signaling in cellular structures.