Related Experiment Video

Updated: May 16, 2025

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

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Bioinformatics exploration of the S1PR1 receptor in various human cancers and its clinical relevance

Xing Xiong1, Li Zeng2, Fanhui Zeng3

  • 1Department of Urology Surgery, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, 330006, China.

Discover Oncology
|April 2, 2025
PubMed
Abstract

Insights

Sphingosine-1-phosphate receptor 1 (S1PR1) is crucial in cancer progression. Its expression, mutations, and modifications suggest S1PR1 is a potential therapeutic target and prognostic biomarker for various cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background:

  • Sphingosine-1-phosphate receptor 1 (S1PR1) is vital for cell migration, proliferation, and survival.
  • Its role in cancer pathogenesis is not fully understood, unlike its established functions in cardiovascular and immune systems.

Purpose of the Study:

  • To investigate the expression, mutations, post-translational modifications, and immune infiltration of S1PR1 across diverse cancer types.
  • To evaluate S1PR1's potential as a therapeutic target and prognostic biomarker in oncology.

Main Methods:

  • Utilized bioinformatics databases (HPA, GTEx, TCGA, CPTAC) for S1PR1 expression analysis.
  • Assessed sequence conservation and phylogenetic analysis via NCBI and Pfam.
  • Analyzed gene mutations, methylation, phosphorylation, and immune infiltration using cBioPortal, MethSuv, CPTAC, and TIMER2.0.

Main Results:

  • S1PR1 expression varied significantly across cancers, with notable decreases in bladder/breast cancers and increases in renal cell carcinoma, thyroid cancer, and acute myeloid leukemia.
  • Frequent S1PR1 mutations were found in endometrial, lung, and ovarian cancers. Reduced methylation in lung adenocarcinoma correlated with better survival.
  • Elevated S1PR1 phosphorylation occurred in glioblastoma and renal carcinoma, with immune infiltration linked to cancer-associated fibroblasts (CAFs) and γδ T cells.

Conclusions:

  • S1PR1's expression, mutations, and modifications critically influence cancer progression.
  • S1PR1 emerges as a promising biomarker and therapeutic target, warranting further clinical validation.
Keywords:
CancerMethylationMutationPhosphorylationS1PR1Tumor microenvironment

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