Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

3.9K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
3.9K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

56
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
56

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Continuous infusion [<sup>11</sup>C]-(+)-PHNO PET for measuring dopamine D<sub>2/3</sub> receptor availability and amphetamine effects across the brain: Feasibility and test-retest reliability.

European journal of nuclear medicine and molecular imaging·2026
Same author

[<sup>18</sup>F]FDG functional PET revisited: A new perspective on the temporal dynamics of brain glucose metabolism.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Prognostic Value of <sup>18</sup>F-FDG and <sup>18</sup>F-FEC Uptake in Hepatocellular Carcinoma Using Contrast-Enhanced Integrated PET/MRI: Correlation with Histology and Survival.

Cancers·2026
Same author

Imaging pulmonary P-glycoprotein activity with aerosolized [<sup>99m</sup>Tc]Tc-sestamibi in mice.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2026
Same author

Intraprostatic PSMA PET/MRI parameters and clinical markers for ISUP prediction and postoperative biochemical recurrence in patients with primary prostate cancer.

European journal of nuclear medicine and molecular imaging·2026
Same author

High-temporal resolution metabolic connectivity resolved by component-based noise correction.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Ventricular CSF-to-blood water transport kinetics in adult hydrocephalus.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Intercellular Mitochondrial Transfer in Ischemic Stroke: Emerging Roles of Microglia.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Mechanical Compaction Alters Microstructural and Magnetic Resonance Imaging Properties of Acute Ischemic Stroke Clots.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Multi-modal Magnetic Resonance Imaging to Assess Cerebrovascular Function in Patients with Atrial Fibrillation.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Trifluoperazine reduces infarct size, restores neurovascular coupling and improves early outcomes in experimental acute ischemic stroke.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Advances in artificial intelligence for neuroimaging.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
See all related articles

Related Experiment Video

Updated: May 16, 2025

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm
06:53

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Published on: July 23, 2020

5.5K

Optimal filtering strategies for task-specific functional PET imaging.

Murray Bruce Reed1,2, Magdalena Ponce de León1,2, Sebastian Klug1,2

  • 1Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|April 2, 2025
PubMed
Summary
This summary is machine-generated.

This study evaluated filtering techniques for functional Positron Emission Tomography (fPET) imaging. The extended dynamic Non-Local Means (edNLM) filter demonstrated superior performance in enhancing signal quality and reducing sample size for brain imaging studies.

Keywords:
Functional Positron Emission Tomography (fPET)MRI-Markov Random Field (MRI-MRF)[18F]2-fluoro-2-deoxy-D-glucose ([18F]FDG)filteringhighly constrained back projection (HYPR)non-local means (NLM)

More Related Videos

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

9.9K
Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
14:21

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

Published on: August 6, 2013

18.2K

Related Experiment Videos

Last Updated: May 16, 2025

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm
06:53

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Published on: July 23, 2020

5.5K
Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

9.9K
Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
14:21

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

Published on: August 6, 2013

18.2K

Area of Science:

  • Neuroimaging
  • Medical Physics
  • Biomedical Engineering

Background:

  • Functional Positron Emission Tomography (fPET) is crucial for investigating brain function and diseases by analyzing dynamic metabolic and neurotransmitter processes.
  • Optimizing signal processing in fPET is essential for accurately extracting task-specific information and improving diagnostic capabilities.

Purpose of the Study:

  • To systematically evaluate and compare state-of-the-art filtering techniques for fPET imaging.
  • To assess the impact of different filters on key performance metrics including reliability, signal-to-noise ratio, and spatial activation.
  • To determine the optimal filter for reducing sample size requirements in fPET studies.

Main Methods:

  • Forty healthy participants underwent [18F]FDG PET/MR scans while performing a cognitive task (Tetris®).
  • Seven filtering techniques (3D/4D Gaussian, HYPR, IHYPR4D, MRI-MRF, dNLM, edNLM) were applied and evaluated using various hyperparameters.
  • Performance was assessed via test-retest reliability, temporal signal-to-noise ratio (tSNR), spatial activation mapping, and sample size calculations.

Main Results:

  • The extended dynamic Non-Local Means (edNLM) filter, along with dNLM, MRI-MRF, and IHYPR4D, significantly improved tSNR compared to 3D Gaussian smoothing.
  • edNLM and HYPR filters notably enhanced test-retest reliability.
  • NLM filters and MRI-MRF approaches improved spatial task-based activation, with edNLM reducing the required sample size by 15.4%.

Conclusions:

  • The extended dynamic Non-Local Means (edNLM) filter exhibits promising performance across multiple critical metrics for fPET analysis.
  • Filter selection in fPET imaging should be tailored to specific research objectives and available resources, considering trade-offs in performance.
  • Optimized filtering techniques can enhance the efficiency and reliability of fPET studies, potentially reducing participant numbers and improving insights into brain dynamics.