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Rheumatoid factor isotypes following immunization.

P R Levine, D A Axelrod

    Clinical and Experimental Rheumatology
    |April 1, 1985
    PubMed
    Summary
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    Multiple immunizations can cause rheumatoid factor (RF) positivity detected by sensitive enzyme-linked immunosorbent assays (ELISA). This RF increase in healthy subjects is often missed by standard clinical detection methods.

    Area of Science:

    • Immunology
    • Clinical Chemistry

    Background:

    • Rheumatoid factors (RF) are autoantibodies commonly associated with rheumatoid arthritis.
    • Standard diagnostic tests for RF may have limitations in sensitivity.

    Purpose of the Study:

    • To investigate the prevalence of rheumatoid factor (RF) positivity following multiple immunizations in healthy subjects.
    • To compare the sensitivity of enzyme-linked immunosorbent assay (ELISA) with standard sheep-cell agglutination tests for RF detection.

    Main Methods:

    • Serum samples from 422 healthy individuals were analyzed before and four weeks after immunization.
    • Samples were tested for IgM RF using both ELISA and a standard sheep-cell agglutination test.

    Main Results:

    • Increased IgM RF levels were detected in 22% of subjects using ELISA.

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  • This increase in RF was not detectable by the standard sheep-cell agglutination test.

    • Conclusions:

    • Sensitive assays like ELISA can detect RF positivity induced by immunizations in healthy individuals.
    • Standard clinical methods may not identify RF elevations caused by immunization, suggesting a need for assay awareness.