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Striasteroids A-C, Three Hybrid Steroids with Neuraminidase Inhibitory Activities from a Marine-Derived
Chunmei Chen1,2, Jian Cai1,2, Chun Yang3
1State Key Laboratory of Tropical Oceanography/CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Abstract:
Three unprecedented hybrid steroids, striasteroids A-C (1-3), together with a known analogue (4), were isolated from the fungus Striaticonidium cinctum SCSIO41432. Their structures were identified through spectroscopic data, X-ray crystallography, and electronic circular dichroism calculations. Compounds 1 and 2, which feature a new 6/6/6/6/6/5 hexacyclic framework, are polyketide-steroid hybrids with an oxabicyclo[3.3.1]nonane-bridged system. Compound 3, characterized as the first naturally occurring adenine-steroid hybrid, exhibited the most potent inhibitory activity against neuraminidase with an IC50 value of 6.15 ± 1.15 μM.
