Bibliometric and graphical analysis of ferroptosis and aging research: Trends, gaps, and future directions

Siyang Cao ¹, Yingchen Pang ², Yihao Wei ³

¹National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, PR China; Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, PR China; Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, PR China.
²Department of Pulmonary and Critical Care Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, PR China; Department of Pulmonary and Critical Care Medicine, Shenzhen Xinhua Hospital, Shenzhen, Guangdong, PR China.
³Department of Rehabilitation Science, The Hong Kong Polytechnic University, Hong Kong; Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen, Guangdong, PR China; Faculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology, Shenzhen, Guangdong, PR China.
⁴Department of Radiology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, PR China.
⁵National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, PR China; Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, PR China; Department of Orthopedics, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, PR China.

⁰National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, PR China; Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, PR China; Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, PR China.

Pathology, Research and Practice +

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April 2, 2025

View abstract on PubMed

Summary

Ferroptosis, a cell death pathway, is increasingly linked to aging mechanisms. This bibliometric analysis maps 12 years of research, revealing key trends, contributors, and disease connections in ferroptosis and aging studies.

Area Of Science

Biomedical Sciences
Gerontology
Cell Biology

Background

Ferroptosis, a regulated form of cell death, has emerged as a critical factor in aging processes.
Despite growing interest, a comprehensive bibliometric analysis of ferroptosis and aging research trends is lacking.

Purpose Of The Study

To provide an exhaustive overview of ferroptosis and aging research from 2012 to 2024.
To identify key research directions, trends, focal points, and future outlooks in this interdisciplinary field.

Main Methods

Bibliometric and visual analyses of publications from the Web of Science database (Jan 2012 - June 2024).
Identification of leading countries, institutions, researchers, journals, and research topics.

Main Results

China leads global research output (48.52%).
Columbia University, Southern Medical University, and Salk Institute are top institutions.
Pamela Maher and Gu Wei are most prolific authors.
Key research areas include mitochondrial diseases, Parkinson's disease, and hepatocellular carcinoma.

Conclusions

This study provides critical insights into the evolving landscape of ferroptosis and aging research.
It serves as a valuable resource for researchers seeking to identify emerging trends and potential research avenues.

Keywords:

Aging Bibliometrics Ferroptosis Senescence Visualization analysis

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