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Updated: May 20, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
Underestimation of lung regions on chest X-ray segmentation masks assessed by comparison with total lung volume
P Bombiński1, P Szatkowski2, B Sobieski3
1Department of Pediatric Radiology, Medical University of Warsaw, Pediatric Clinical Hospital, 63A Żwirki i Wigury St, Warsaw 02-091, Poland; upmedic, 2/11 Sądowa St, 20-027 Lublin, Poland.
Introduction:
The lung regions on chest X-ray segmentation masks created according to the current gold standard method for AI-driven applications are underestimated. This can be evaluated by comparison with computed tomography.
Methods:
This retrospective study included data from non-contrast chest low-dose CT examinations of 55 individuals without pulmonary pathology. Synthetic X-ray images were generated by projecting a 3D CT examination onto a 2D image plane. Two experienced radiologists manually created two types of lung masks: 3D lung masks from CT examinations (ground truth for further calculations) and 2D lung masks from synthetic X-ray images (according to the current gold standard method: following the contours of other anatomical structures). Overlapping and non-overlapping lung regions covered by both types of masks were analyzed. Volume of the overlapping regions was compared with total lung volume, and volume fractions of non-overlapping lung regions in relation to the total lung volume were calculated. The performance results between the two radiologists were compared.
Results:
Significant differences were observed between lung regions covered by CT and synthetic X-ray masks. The mean volume fractions of the lung regions not covered by synthetic X-ray masks for the right lung, the left lung, and both lungs were 22.8 %, 32.9 %, and 27.3 %, respectively, for Radiologist 1 and 22.7 %, 32.9 %, and 27.3 %, respectively, for Radiologist 2. There was excellent spatial agreement between the masks created by the two radiologists.
Conclusions:
Lung X-ray masks created according to the current gold standard method significantly underestimate lung regions and do not cover substantial portions of the lungs.
Implications For Practice:
Standard lung masks fail to encompass the whole range of the lungs and significantly restrict the field of analysis in AI-driven applications, which may lead to false conclusions and diagnoses.
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