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Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
Research progress on the regulatory role of different cell death pathways in metabolic-dysfunction-associated
Congyue Zhang1, Mengjiao Sun1, Yuanjian Ding2
1Department of Integrated Traditional Chinese and Western Medicine Hepatology, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, China.
Abstract:
Metabolic dysfunction associated steatotic liver disease (MASLD) is one of the most common chronic liver diseases that pose a significant threat to human health. An essential process in developing various diseases, including MASLD, is programmed cell death, a regulated and controlled mechanism that eliminates damaged or unnecessary cells. It is a ubiquitous process during organismal development and represents an active, orderly form of cell death. Significant progress has been made in studying programmed cell death in the context of MASLD. This review systematically summarizes various forms of cell death, including apoptosis, Pyroptosis, autophagy, ferroptosis, and cuproptosis, along with their regulatory mechanisms in MASLD. It has been observed that there are interactions between different forms of cell death. As MASLD progresses through inflammation, fibrosis, and cirrhosis stages, multiple forms of cell death may act synergistically. This article aims to provide the latest research findings and theoretical insights to further our understanding of the pathogenesis of MASLD.
Insights
Metabolic dysfunction associated steatotic liver disease (MASLD) involves programmed cell death pathways. Understanding these cell death mechanisms is crucial for MASLD pathogenesis and treatment.
Area of Science:
- Hepatology
- Cell Biology
- Molecular Medicine
Background:
- Metabolic dysfunction associated steatotic liver disease (MASLD) is a prevalent chronic liver condition with significant health implications.
- Programmed cell death is a fundamental biological process implicated in the development of various diseases, including MASLD.
- MASLD pathogenesis involves complex cellular mechanisms, with programmed cell death playing a critical role.
Purpose of the Study:
- To systematically review various forms of programmed cell death in MASLD.
- To elucidate the regulatory mechanisms of different cell death pathways in MASLD.
- To explore the synergistic interactions between distinct cell death modalities during MASLD progression.
Main Methods:
- Systematic literature review of programmed cell death in MASLD.
- Analysis of regulatory mechanisms for apoptosis, pyroptosis, autophagy, ferroptosis, and cuproptosis.
- Examination of the interplay between different cell death types in MASLD stages.
Main Results:
- Multiple programmed cell death pathways, including apoptosis, pyroptosis, autophagy, ferroptosis, and cuproptosis, are involved in MASLD.
- These cell death pathways are intricately regulated and interact with each other.
- Synergistic effects of various cell death forms are observed as MASLD advances through inflammation, fibrosis, and cirrhosis.
Conclusions:
- Programmed cell death is a key player in the pathogenesis of MASLD.
- Understanding the diverse and interacting cell death mechanisms offers novel therapeutic targets.
- Further research into these pathways will enhance our comprehension of MASLD progression and management.
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