Development of iron oxide based-upconversion nanocomposites for cancer therapeutics treatment

Administration of therapeutic strategies alongside magnetic multifunctional nanocomposites has displayed improved cancer prognosis. However, the clinical use of this combination is limited owing to poor bioimaging performance, low biocompatibility, restricted tissue penetration in ultraviolet/visible regions, and low therapeutic efficacy of nanocomposites. To overcome these existing challenges, we designed iron oxide (Fe₃O₄)-based upconversion nanoparticles (UCNPs). Fe₃O₄ nanoparticles were synthesized via facile solvothermal method and incorporated into mesoporous silica (mS) layer (Fe₃O₄@mS). Fe₃O₄@mS nanoparticles were further decorated onto the surface of the UCNPs as a core material (UCNP-Fe₃O₄@mS, FMUP). Methotrexate (MTX) an efficient anticancer drug was loaded onto the mesoporous silica to produce FMUP-MTX nanocomposite. The FMUP nanocomposite displayed excellent photothermal therapy and showed 43% photothermal conversion efficiency. The designed nanocomposite has ability to decompose H₂O₂ to generates hydroxyl radical that promote chemodynamic therapy effect due to attribution of Fenton reaction. FMUP-MTX nanocomposite possessed improved chemotherapeutic performance under NIR laser irradiation. Further, T₂-weighted magnetic resonance imaging performance of nanocomposite was observed. In vitro studies shown that cell viability was decreased to 25% under laser irradiation due to the therapeutic effect. In vivo studies exhibited that the FMUP-MTX nanocomposite inhibited the tumor growth with the laser irradiation. Therefore, these nanocomposites can be considered as a promising candidate for cancer therapeutics treatment.