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Related Experiment Video

Updated: Jun 4, 2026

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Published on: December 11, 2016

Advancing Age Is Not Associated With Greater Exercise-Induced Muscle Damage: A Systematic Review, Meta-Analysis, and

John F T Fernandes¹, Laura J Wilson², Amelia F Dingley³

¹School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, United Kingdom.

Journal of Aging and Physical Activity

|April 2, 2025

Summary

Older adults do not experience greater exercise-induced muscle damage (EIMD) compared to younger adults. This finding suggests that older individuals can engage in regular physical activity without increased concern for muscle damage.

Keywords:

creatine kinase eccentric exercise fatigue muscle function muscle soreness recovery

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Last Updated: Jun 4, 2026

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

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Published on: December 11, 2016

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

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Published on: July 5, 2017

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage

Published on: August 31, 2022

Area of Science:

Gerontology
Exercise Physiology
Sports Medicine

Background:

Exercise-induced muscle damage (EIMD) is a common response to strenuous physical activity.
Concerns exist regarding the potential for increased EIMD in older adults due to age-related physiological changes.

Purpose of the Study:

To conduct a meta-analysis comparing EIMD between older and younger adults.
To determine if advancing age is associated with heightened EIMD symptoms.

Main Methods:

A systematic search of databases (Google Scholar, PubMed, SPORTDiscus) was performed.
Included studies compared EIMD outcomes (muscle function, soreness, creatine kinase) between younger and older groups.
A random effects model was used for meta-analysis of standardized mean differences (SMD).

Main Results:

No significant differences in muscle function changes were observed between age groups.
Younger adults reported greater muscle soreness than older adults.
Creatine kinase levels were higher in younger adults at 24 hours post-exercise.

Conclusions:

Advancing age is not linked to increased EIMD.
Older adults can safely participate in regular physical activity without fear of greater muscle damage.