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Monoclonal Antibodies for Pediatric Viral Disease Prevention and Treatment

Zeynep Bahadir1, Priyanka Narayan1, Rachael Wolters2

  • 1Department of Pediatrics, Weill Cornell Medicine, Cornell University, New York, New York.

Pediatrics
|April 2, 2025
PubMed

Insights

Human monoclonal antibodies (mAbs) offer a promising strategy for treating and preventing viral infections in children. This review explores current and future mAb therapies for pediatric viral diseases.

Area of Science:

  • Pediatric Infectious Diseases
  • Immunology
  • Virology
  • Drug Development

Background:

  • Medical progress has reduced pediatric infectious disease mortality, but many viral pathogens lack vaccines.
  • The COVID-19 pandemic underscored the need for rapid antiviral responses and new therapeutic tools.
  • Human monoclonal antibodies (mAbs) are emerging as a key strategy in combating viral infections.

Purpose of the Study:

  • To review the use of human monoclonal antibodies (mAbs) for treating and preventing viral infections in pediatric populations.
  • To discuss advancements in mAb discovery, production, and delivery platforms.
  • To explore challenges and limitations of mAb therapy in newborns and children.

Main Methods:

  • Literature review of existing and emerging human monoclonal antibody (mAb) therapies for viral infections.
  • Analysis of novel approaches in drug production and delivery systems for pediatric mAb treatments.
  • Examination of alternative antibody classes and their potential in pediatric viral disease management.

Main Results:

  • Monoclonal antibodies (mAbs) have shown efficacy in treating and preventing various viral infections.
  • Advancements in mAb discovery and production are accelerating therapeutic development.
  • Novel delivery platforms and alternative antibody classes present future opportunities for pediatric mAb therapy.

Conclusions:

  • Human monoclonal antibodies (mAbs) represent a vital therapeutic avenue for pediatric viral infections.
  • Continued research into novel mAb platforms and delivery systems is crucial for pediatric applications.
  • Addressing challenges in development and accessibility will enhance mAb therapy for newborns and children.

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