Related Experiment Video
Updated: May 17, 2025
14:39
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
31.8K
Con: clinical remission in asthma - not yet there
Lauren Eggert1, Sarah Rhoads2, Michael E Wechsler3
1Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA, USA.
Summary
Defining asthma remission is challenging due to symptom variability, lung function changes, and comorbidities. Current definitions need improvement for practical, measurable, and meaningful clinical application in asthma management.
Area of Science:
- Pulmonology
- Clinical Medicine
- Asthma Research
Background:
- Defining asthma remission is crucial for assessing true disease modification.
- Current definitions lack practicality, measurability, and clinical meaning for patients and physicians.
- Asthma's inherent complexities pose significant challenges to establishing a consensus definition.
Purpose of the Study:
- To discuss the obstacles and challenges in developing a widely adopted, consensus definition of asthma remission.
- To highlight the difficulties in creating a definition that is practical, measurable, and meaningful.
- To explore the concept of 'super-responders' in the context of asthma remission.
Main Methods:
- Literature search using keywords: "asthma", "remission", and "super-responder".
- Identification and analysis of interventional trials in asthma.
- Discussion of challenges based on existing research and clinical observations.
Main Results:
- Current proposals for asthma remission definitions are inadequate.
- Variability in symptom perception, lung function, seasonality, and comorbidities complicate definition development.
- Interventional trials reveal inherent challenges in defining asthma remission.
Conclusions:
- Developing a universally accepted definition for asthma remission remains a significant challenge.
- Overcoming obstacles related to asthma's heterogeneity is essential for a practical and meaningful definition.
- Further research is needed to refine criteria for asthma remission and disease modification.
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