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Pro: Clinical remission in asthma - implications for asthma management
Stefania Principe1, Nizar N Jarjour2
1Amsterdam UMC, Location Vrije University Medical Center, Department of Respiratory Medicine, Amsterdam, The Netherlands.
Summary
Asthma biologics offer a new path toward remission, characterized by controlled symptoms and improved lung function. Achieving asthma remission requires a common definition and proactive management for better long-term patient outcomes.
Area of Science:
- Pulmonology
- Immunology
- Pharmacology
Background:
- Despite advancements, many asthma patients experience persistent symptoms and exacerbations.
- Biologics represent a significant advancement in severe asthma management, targeting molecular pathways.
- Achieving asthma remission is a new therapeutic possibility.
Purpose of the Study:
- To review studies supporting asthma remission as a management goal.
- To highlight the role of biologics in achieving remission.
- To discuss the implications of remission for asthma care.
Main Methods:
- Comprehensive literature review of studies on asthma remission and biologics.
- Analysis of real-world data and post-hoc clinical trial results.
- Examination of current definitions and indicators of asthma remission.
Main Results:
- Biologics show potential for achieving clinical remission in a significant patient proportion.
- Key indicators of remission include high asthma control, no exacerbations, and stable lung function.
- Current definitions of remission lack universal consensus.
Conclusions:
- Asthma remission should be considered a potential management goal.
- Proactive management focusing on long-term outcomes is crucial.
- Further prospective studies are needed to establish a universal definition for remission.
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