Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

2.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
2.8K
Disorders of Leukocytes01:27

Disorders of Leukocytes

782
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
782
Necrosis01:16

Necrosis

3.7K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
3.7K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

162
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
162
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.0K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.0K
Proteoglycans01:05

Proteoglycans

3.8K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-Term Outcomes of Mayo Stage IIIb AL Amyloidosis Treated With Daratumumab-Based Frontline Therapy.

American journal of hematology·2026
Same author

Obinutuzumab or Tacrolimus in Primary Membranous Nephropathy.

The New England journal of medicine·2026
Same author

New and Emerging Nonimmunosuppressive Drug Therapies for Primary Adult Glomerular Diseases.

Kidney medicine·2026
Same author

Pegcetacoplan Versus Iptacopan for the Treatment of Patients with C3 Glomerulopathy: Indirect Treatment Comparisons.

Advances in therapy·2026
Same author

Kidney International introduces new article type: Clinical Journey in Translational Medicine.

Kidney international·2026
Same author

Complement 3 Glomerulopathy (C3G) in Native and Posttransplant Kidneys: A Review.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

New Drugs on the Horizon for Hypertension.

Advances in kidney disease and health·2026
Same journal

Hyperammonemia Physiology and Management: A Nephrology-Centered Review.

Advances in kidney disease and health·2026
Same journal

Hypertension in Advanced Chronic Kidney Disease: Saving the Kidneys or the Heart?

Advances in kidney disease and health·2026
Same journal

Social Determinants of Health and Primary Hypertension in Children and Adolescents: Proposed Solutions Using a Socioecological Model of Health.

Advances in kidney disease and health·2026
Same journal

Blood Pressure Management in the Inpatient and Acute Care Setting.

Advances in kidney disease and health·2026
Same journal

Endocrine Hypertension in Children and Adults: Beyond Primary Aldosteronism.

Advances in kidney disease and health·2026
See all related articles

Related Experiment Video

Updated: May 17, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

998

Podocytopathies.

Mariela Navarro-Torres1, Benjamin Wooden1, Dominick Santoriello1

  • 1Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY.

Advances in Kidney Disease and Health
|April 2, 2025
PubMed
Summary
This summary is machine-generated.

Podocytopathies, including focal segmental glomerulosclerosis and minimal change disease, require prompt diagnosis and treatment. Primary forms and minimal change disease often need immunosuppression, unlike genetic podocytopathies.

Keywords:
EdemaFocal segmental glomerulosclerosisMinimal change diseaseNephrotic syndromeProteinuria

More Related Videos

Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications
10:12

Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications

Published on: April 21, 2023

2.6K
Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

13.1K

Related Experiment Videos

Last Updated: May 17, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

998
Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications
10:12

Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications

Published on: April 21, 2023

2.6K
Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

13.1K

Area of Science:

  • Nephrology
  • Pathology

Background:

  • Podocytes are vital cells in the glomerular filtration barrier.
  • Podocyte injury leads to podocytopathies, such as focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD).

Purpose of the Study:

  • To review key diagnostic and treatment strategies for podocytopathies.
  • To differentiate between primary and secondary causes of podocytopathies.

Main Methods:

  • Review of clinical presentations and kidney biopsy findings.
  • Classification of podocytopathies into primary or secondary forms.

Main Results:

  • FSGS and MCD present with variable clinical and biopsy features.
  • Primary FSGS and MCD typically require immunosuppression due to rare spontaneous remission.
  • Secondary FSGS may have different treatment considerations.
  • Genetic podocytopathies generally do not require immunosuppression, with exceptions for specific populations.

Conclusions:

  • Accurate classification of podocytopathies is crucial for guiding treatment.
  • Immunosuppression is a cornerstone for primary FSGS and MCD.
  • Treatment decisions for podocytopathies must consider the underlying cause and patient-specific factors.