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Related Concept Videos

Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

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Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
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Single-Cell Optical Action Potential Measurement in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
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High-Efficiency ICG Molecular Vibration Therapy for Bradyarrhythmia Using Cardiomyocyte-Based Biosensing.

Xuelian Lyu1, Tao Liang1,2, Jilin Zheng1

  • 1Department of Chemistry, Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials, ZJU-Hangzhou Global Scientific and Technological Innovation Center, School of Medicine, Zhejiang University, Hangzhou 310058, China.

ACS Sensors
|April 2, 2025
PubMed
Summary

A novel photothermal therapy using indocyanine green (ICG) offers a noninvasive treatment for bradyarrhythmia. This drug-mimicking strategy effectively enhances cardiomyocyte electrophysiology, providing a promising alternative to conventional therapies.

Keywords:
cardiomyocyte-based bradyarrhythmiadrug-mimickingelectrophysiologyindocyanine greenmolecular vibration

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Nanomedicine

Background:

  • Bradyarrhythmia significantly contributes to cardiovascular disease morbidity and mortality.
  • Current treatments like medication and surgery have limitations, including side effects and invasiveness.
  • There is a critical need for alternative, less invasive therapeutic strategies for bradyarrhythmia.

Purpose of the Study:

  • To develop and evaluate a universal, efficient drug-mimicking strategy for bradyarrhythmia treatment.
  • To utilize the photothermal properties of indocyanine green (ICG) for therapeutic purposes.
  • To establish an integrated cell-based biosensing-regulating platform for assessing treatment efficacy.

Main Methods:

  • A drug-mimicking strategy employing near-infrared-triggered indocyanine green (ICG) was developed.
  • An in situ integrated cell-based biosensing-regulating platform was created to monitor cardiomyocyte electrophysiology.
  • The efficacy of ICG photothermal therapy was compared with Au nanorod plasmonic heating.

Main Results:

  • ICG photothermal therapy demonstrated efficient enhancement of cardiomyocyte electrophysiology in bradyarrhythmia models.
  • The treatment successfully maintained a rhythmic state in cardiomyocytes for extended periods.
  • Thermal stimulation was identified as the key factor in improving cardiomyocyte electrophysiological activity.

Conclusions:

  • This study presents a noninvasive, drug-mimicking photothermal treatment strategy for bradyarrhythmia using ICG.
  • The developed biosensing-regulating platform provides a reliable method for electrophysiological assessment and drug screening.
  • This approach holds significant potential for advancing bradyarrhythmia therapies.