Dopamine fast determination in pharmaceutical products using disposable printed electrodes modified with bimetal...

Dopamine is an essential neurotransmitter involved in the regulation of our pleasure, motivation, and other biological functions. Thus, tracking and monitoring the biological dopamine level is crucial for the rapid and effective treatment as well as for the diagnosis of the neurodegenerative and neurological disorders. Nanostructured electrochemical systems are tested and validated as promising methods for dopamine detection. In this study, carbon nanotube-anchored bimetallic manganese/copper bi-oxides nanocomposite-modified screen-printed carbon electrodes (Mn/Cu oxides @CNTs-SPCEs) were exploited for the electrocatalytic oxidation and direct determination of dopamine. From the morphological analysis, the particle size of the bimetallic oxides spherical nanoparticles was ranged from 9.0 to 45 nm, while the electrocatalytic activity of nanocomposite towards dopamine oxidation was examined by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) to demonstrate the acquired high sensitivity and selectivity. The optimized DPV assay provided a wide linear dynamic range of dopamine concentrations (from 0.001 to 140 µM), and a low detection limit of 0.3 nM. Eventually, the newly modified electrochemical method was applied for dopamine detection in pharmaceutical products with high accuracy.