Correlation and prognosis analysis of human papillomavirus infection and P16 expression in oral and oropharyngeal squamous cell carcinomas
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View abstract on PubMed
Summary
This summary is machine-generated.Human papillomavirus (HPV) DNA and P16 protein expression are more common in oropharyngeal squamous cell carcinoma (OPSCC) than oral squamous cell carcinoma (OSCC). P16 is a useful biomarker for HPV-related OPSCC but not OSCC, with age and stage impacting OSCC prognosis.
Area Of Science
- Oncology
- Virology
- Pathology
Background
- The incidence of human papillomavirus (HPV)-related oral squamous cell carcinomas (OSCC) and oropharyngeal squamous cell carcinomas (OPSCC) is rising.
- The specific roles of HPV and P16 protein in the development and prognosis of OSCC and OPSCC remain incompletely understood and debated.
Purpose Of The Study
- To investigate the prevalence and prognostic significance of HPV-DNA, HPV E6E7, and P16 protein expression in OSCC and OPSCC.
- To explore the correlation between P16 protein expression and HPV infection in these cancer types.
- To determine the clinical utility of P16 as a biomarker for HPV-related OSCC and OPSCC.
Main Methods
- Analysis of HPV-DNA, HPV E6E7, and P16 protein expression in patient cohorts of OSCC and OPSCC.
- Statistical evaluation of the prevalence of these markers in relation to tumor type, differentiation, and clinical parameters.
- Correlation analysis between P16 expression and HPV infection status.
- Prognostic analysis assessing the impact of HPV DNA and P16 expression on disease-free survival (DFS) and overall survival (OS).
Main Results
- HPV DNA infection rate was significantly higher in OPSCC (16.7%) compared to OSCC (3.6%).
- HPV DNA positivity correlated with poorly differentiated tumors (P=0.009).
- P16 (+++) expression was significantly more frequent in OPSCC (12.5%) than OSCC (0.7%).
- P16 (+++) demonstrated a sensitivity of 62.5% for detecting HPV DNA in OPSCC.
- Neither HPV DNA nor P16 (+++) expression was significantly linked to prognosis in either OSCC or OPSCC.
- In OSCC, age, T, N, and clinical stage correlated with prognosis. In OPSCC, younger age was associated with a better prognosis.
Conclusions
- P16 (+++) serves as a reliable biomarker for HPV-related high-risk tumors in OPSCC but not in OSCC.
- Prognostic factors in OSCC include patient age, tumor size (T), lymph node involvement (N), and clinical stage.
- Younger age is a favorable prognostic indicator for patients with OPSCC.
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