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Structural basis for membrane remodeling by the AP5-SPG11-SPG15 complex.

Xinyi Mai1, Yang Wang1, Xi Wang1

  • 1Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong, China.

Nature Structural & Molecular Biology
|April 2, 2025
PubMed
Summary

The spastizin (SPG15) and spatacsin (SPG11) complex, crucial for lysosome formation and linked to spastic paraplegia, interacts with the AP5 complex. This AP5-SPG11-SPG15 complex remodels membranes, essential for autolysosome tubulation.

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