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"SERBP1 (Hero45) is a Novel Link with Ischemic Heart Disease Risk: Associations with Coronary Arteries Occlusion,

Vladislav Shilenok1,2, Ksenia Kobzeva1, Olga Bushueva3,4

  • 1Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, Kursk, Russia.

Cell Biochemistry and Biophysics
|April 2, 2025
PubMed

Insights

Single nucleotide polymorphisms (SNPs) in the SERBP1 gene are associated with a reduced risk of ischemic heart disease (IHD). This finding highlights SERBP1

Area of Science:

  • Cardiovascular Genetics
  • Molecular Biology
  • Genetics

Background:

  • Ischemic heart disease (IHD) arises from coronary atherosclerosis, a process where chaperone proteins are crucial.
  • SERBP1 (Hero45), an RNA-binding protein with chaperone-like activity, is implicated in atherosclerosis-related diseases.

Purpose of the Study:

  • To investigate the association between SERBP1 single nucleotide polymorphisms (SNPs) and the risk of ischemic heart disease (IHD).
  • To explore the role of SERBP1 in lipid metabolism and coagulation regulation in the context of IHD.

Main Methods:

  • Genotyping of five common SERBP1 SNPs in 2164 subjects (836 IHD patients, 1328 controls) using probe-based PCR.
  • Statistical analysis to determine the association between SERBP1 SNPs and IHD risk, coronary artery stenosis, lipid profiles, and coagulation parameters.

Main Results:

  • Specific SERBP1 SNPs (rs4655707, rs12561767, rs6702742) were significantly associated with a reduced risk of left coronary artery atherosclerosis.
  • SERBP1 loci were linked to lower coronary artery stenosis, improved blood lipid profiles, and favorable blood coagulation parameters.
  • The study identified novel associations between SERBP1, lipid metabolism, and coagulation regulation.

Conclusions:

  • SERBP1 SNPs are associated with a reduced risk of ischemic heart disease.
  • SERBP1 plays a role in modulating IHD risk through its influence on lipid metabolism and coagulation.
  • This research provides the first evidence linking SERBP1 to lipid metabolism and coagulation regulation in the context of IHD.

Keywords:
ChaperoneHero45SERBP1ThrombosisTotal cholesterolrs1058074

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