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Evaluating the predictive value of log odds of positive lymph nodes on postoperative survival in patients with

Jiahui Zhang1,2,3, Wenjun Su2,4, Yue Wang2

  • 1Xiamen Hospital of Traditional Chinese Medicine, Xiamen, China.

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Summary

The log odds of positive lymph nodes (LODDS) combined with TNM staging improves laryngeal cancer prognosis prediction. This new model offers superior accuracy for predicting patient outcomes after surgery.

Keywords:
LODDSLaryngeal cancerPrognostic modelTNM staging

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Area of Science:

  • Oncology
  • Cancer Prognostics
  • Biostatistics

Background:

  • The AJCC TNM staging system is standard for laryngeal cancer prognosis.
  • Log odds of positive lymph nodes (LODDS) shows promise in other cancers but is understudied in laryngeal cancer.

Purpose of the Study:

  • To evaluate the predictive accuracy of LODDS compared to TNM staging for laryngeal cancer.
  • To develop and validate a superior prognostic model for laryngeal cancer.

Main Methods:

  • Analysis of SEER database (2000-2019) data.
  • Univariate and multivariate Cox regression for risk factor identification.
  • Prognostic model construction and evaluation using ROC curves and AUC values.

Main Results:

  • LODDS subgroup, age, marital status, histologic grade, T-stage, and N-stage are independent prognostic factors for overall survival (OS) and cancer-specific survival (CSS).
  • A multivariate model integrating LODDS and N staging demonstrated superior predictive performance over individual models.
  • The combined model outperformed TNM staging alone in predicting postoperative prognosis.

Conclusions:

  • The multivariate prognostic model incorporating LODDS and N staging is a superior tool for predicting postoperative outcomes in laryngeal cancer.
  • This enhanced model can aid in more accurate patient risk stratification and treatment planning.