Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Surface Membrane Barriers01:18

Surface Membrane Barriers

747
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
747
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Antibiotic Selection00:57

Antibiotic Selection

52.0K
Overview
52.0K
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

3.6K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
3.6K
Bacterial Signaling01:30

Bacterial Signaling

30.9K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
30.9K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

10.6K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
10.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma-induced chemical and structural activation of 2D nanomaterial coatings for antibacterial surfaces.

Nanoscale·2026
Same author

Photodynamically active AIE-functionalised casein nanofibers for antibacterial wound management in epidermolysis bullosa.

Journal of materials chemistry. B·2026
Same author

Targeting hemozoin detoxification in Plasmodium falciparum: could a chlorophyll derivative act as a tetrapyrrole mimic to disrupt hemozoin formation in infected erythrocytes?

MedScience·2026
Same author

Multifunctional Oregano-Derived Plasma Polymer Coatings for Wound Healing Applications: An In Vitro Study.

International wound journal·2026
Same author

Antibacterial ZnO nanoparticle embedded polycaprolactone-polyhydroxybutyrate membranes for wound healing.

Journal of materials science. Materials in medicine·2026
Same author

Randomized, Placebo-Controlled Trial of B-Cell Depletion for Prevention of Corticosteroid-Requiring Chronic Graft-Versus-Host Disease.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026

Related Experiment Video

Updated: May 16, 2025

Surface Potential Measurement of Bacteria Using Kelvin Probe Force Microscopy
10:49

Surface Potential Measurement of Bacteria Using Kelvin Probe Force Microscopy

Published on: November 28, 2014

21.7K

Electrostatic charge at the biomaterial-pathogen interface influences antibiotic efficacy.

Andrew Hayles1, Huu Ngoc Nguyen2,3, Markos Alemie2

  • 1Biomedical Nanoengineering Laboratory, Flinders University, Bedford Park, SA, 5042, Australia. andrew.hayles@flinders.edu.au.

Advanced Biotechnology
|April 2, 2025
PubMed
Summary

Material electrostatic charge affects Staphylococcus aureus

Keywords:
Antibiotic prophylaxisBiomaterialsCoatingDrug toleranceNanotechnologySurface charge

More Related Videos

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance
06:42

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Published on: September 27, 2024

1.3K
High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
10:43

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

9.0K

Related Experiment Videos

Last Updated: May 16, 2025

Surface Potential Measurement of Bacteria Using Kelvin Probe Force Microscopy
10:49

Surface Potential Measurement of Bacteria Using Kelvin Probe Force Microscopy

Published on: November 28, 2014

21.7K
Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance
06:42

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Published on: September 27, 2024

1.3K
High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
10:43

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

9.0K

Area of Science:

  • Biomaterials Science
  • Microbiology
  • Infectious Diseases

Background:

  • Implant-associated infections (IAI) pose a significant global healthcare challenge.
  • Prophylactic antibiotic treatment is crucial for preventing IAI, but bacterial antibiotic tolerance is complex.
  • The role of biomaterial-pathogen interactions in antibiotic tolerance has been underexplored.

Purpose of the Study:

  • To investigate the influence of material electrostatic charge on Staphylococcus aureus physiology.
  • To determine the impact of these biomaterial-pathogen interactions on antibiotic tolerance.
  • To explore personalized biomaterial-antibiotic pairing for enhanced prophylaxis.

Main Methods:

  • Quantitative gene expression analysis.
  • Synchrotron-sourced attenuated total reflectance Fourier-transform microspectroscopy.
  • Characterization of biomaterial-pathogen interactions on charged substrates.

Main Results:

  • Surface attachment to charged substrates alters Staphylococcus aureus phenotype.
  • Material electrostatic properties directly influence the activity of oppositely charged antibiotics (vancomycin, cefazolin).
  • A direct relationship exists between antibiotic efficacy and the biomaterial-pathogen interface charge.

Conclusions:

  • Biomaterial electrostatic charge is a critical factor modulating Staphylococcus aureus antibiotic tolerance.
  • Understanding these interactions can guide personalized antibiotic prophylaxis strategies.
  • This research offers insights to reduce IAI rates by optimizing antibiotic efficacy during implant procedures.