Strategic 1,n-migration of boronate complexes: a novel platform for remote C-C bond construction

Organoboron compounds play a pivotal role in diverse scientific disciplines, including chemistry, materials science, energy research, and medicinal chemistry. In recent years, research efforts have predominantly focused on 1,2-metallate migrations of tetracoordinate boronate complexes, while remote migrations, particularly 1,n-metallate migrations (n > 2), remain challenging due to their inherent complexity. This comprehensive review systematically examines seminal contributions to the field of 1,n-metallate migration reactions (n > 2). Our critical analysis reveals that progress in this domain has been fundamentally driven by the strategic design and synthesis of novel tetracoordinate boron complexes, with a notable evolution from conventional O-B coordination motifs to more sophisticated C-B-bonded architectures. Recent methodological advancements have further expanded the structural diversity and mechanistic understanding of these transformations. Although the number of reported cases remains limited and the research landscape is somewhat fragmented, the existing systems underscore the significance of these migration reactions, drawing considerable attention to this area and inspiring further exploration.