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Prognostic value of [18F]fluorodeoxyglucose-PET/MRI(CT) novel interpretation criteria (IMPeTUs) in multiple myeloma

Miao Zhang1, Tangjia Cai1, Shiwei Jin2

  • 1Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.

European Journal of Nuclear Medicine and Molecular Imaging
|April 2, 2025
PubMed
Abstract

Insights

The Italian Myeloma criteria for PET Use (IMPeTUs) score effectively predicts multiple myeloma (MM) prognosis. This standardized [18F]FDG-PET/MRI score outperforms other markers for progression-free survival in MM patients.

Area of Science:

  • Nuclear Medicine
  • Oncology
  • Radiology

Background:

  • [18F]fluorodeoxyglucose (FDG)-PET is vital for multiple myeloma (MM) prognosis assessment.
  • Standardized interpretation criteria are essential for reliable FDG-PET application in MM.
  • The Italian Myeloma criteria for PET Use (IMPeTUs) has been developed to standardize PET evaluation in MM.

Purpose of the Study:

  • To evaluate the prognostic value of the IMPeTUs score in newly diagnosed multiple myeloma (NDMM).
  • To compare the prognostic performance of the IMPeTUs score against laboratory parameters and SUVmax.
  • To determine if the IMPeTUs score can independently predict progression-free survival (PFS) and overall survival (OS).

Main Methods:

  • 58 NDMM patients underwent both [18F]FDG-PET/MRI and PET/CT at diagnosis.
  • Patients were followed for 42 months for PFS and OS.
  • Prognostic value of IMPeTUs score, SUVmax, and laboratory parameters were analyzed using Kaplan-Meier and Cox regression.

Main Results:

  • The PET/MRI IMPeTUs score demonstrated superior predictive accuracy (AUC=0.760) compared to PET/CT IMPeTUs (AUC=0.711) and other markers.
  • Higher IMPeTUs scores (PET/MRI ≥13, PET/CT ≥10) were significantly associated with worse PFS.
  • PET/MRI IMPeTUs score ≥13 was identified as an independent risk factor for PFS in multivariate analysis.

Conclusions:

  • The IMPeTUs score standardizes [18F]FDG-PET/MRI and PET/CT readings in MM.
  • The IMPeTUs score is a crucial predictor of MM prognosis.
  • IMPeTUs score demonstrates superior prognostic performance compared to SUVmax and clinical indicators.
Keywords:
Italian myeloma criteria for pet use (IMPeTUs )Multiple myeloma (MM)PET/CT[18F]fluorodeoxyglucose (FDG) PET/MRI

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