Related Experiment Video
Updated: May 17, 2025
A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
Published on: March 21, 2025
Development and validation of a framework for registration of whole-mount radical prostatectomy histopathology with
Auke Jager1,2, Marije J Zwart3,4, Arnoud W Postema5
1Department of Urology, Amsterdam UMC location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands. a.jager1@amsterdamumc.nl.
Purpose:
Artificial intelligence (AI) has the potential to improve diagnostic imaging on multiple levels. To develop and validate these AI-assisted modalities a reliable dataset is of utmost importance. The registration of imaging to pathology is an essential step in creating such a dataset. This study presents a comprehensive framework for the registration of 3D transrectal ultrasound (TRUS) to radical prostatectomy specimen (RPS) pathology.
Methods:
The study enrolled patients who underwent 3D TRUS and were scheduled for radical prostatectomy. A four-step process for registering RPS to TRUS was used: image segmentation, 3D reconstruction of RPS pathology, registration and ground truth calculation. Accuracy was assessed using a target-registration error (TRE) based on landmarks visible on both TRUS and pathology.
Results:
20 Sets of 3D TRUS and RPS pathology were included for analyses. The mean TRE was 3.5 mm, (range: 0.4 to 5.4 mm), with TRE values in the apex-base, left-right and posterior-anterior directions of 2.5 mm, 1.1 mm, and 1.4 mm, respectively.
Conclusion:
The framework proposed in this study accomplishes precise registration between prostate pathology and imaging. The methodologies employed hold the potential for broader application across diverse imaging modalities and other target organs. However, limitations such a small sample size and the need for manual segmentation should be considered when interpreting te results. Future efforts should focus on automating key steps to enhance reproducibility and scalability.
