Meta-analysis of altered gray matter volume in acute lymphoblastic leukemia patients' postchemotherapy via the
Xuelian Zong1, Huiping Liu2, Xiaoyun Zhao3
1Department of Hematology, The 940th Hospital of Joint Logistics Support Force of Chinese People'S Liberation Army, Lanzhou, China.
Background:
Voxel-based morphometry (VBM) reveals diverse alterations in gray matter volume in acute lymphoblastic leukemia (ALL) patients after chemotherapy. However, the reported results are inconsistent. Therefore, our objective was to conduct a meta-analysis to synthesize findings from existing VBM studies and identify consistent patterns of altered gray matter volume in ALL patients post-chemotherapy.
Materials And Methods:
A systematic search was conducted across PubMed, Web of Knowledge, Embase, Google Scholar, and CNKI for VBM studies that compared ALL patients post-chemotherapy with healthy controls (HCs) up to April 1, 2024. Significant cluster coordinates were extracted for comprehensive analysis.
Results:
We included 7 studies involving 143 ALL patients post-chemotherapy and 140 HCs. ALL patients who underwent chemotherapy presented decreased gray matter volume in the left caudate nucleus, left calcarine fissure/surrounding cortex, left precentral gyrus and right anterior thalamic projections. Jackknife sensitivity analysis validated the robustness of these findings.
Conclusions:
This meta-analysis revealed consistent gray matter volume alterations in ALL patients post-chemotherapy, emphasizing the need to explore their underlying mechanisms and long-term effects on cognitive and neurological health.
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