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Related Experiment Videos

Studies in experimental keratomycosis.

D M O'Day

    Current Eye Research
    |March 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Rabbit models for fungal infections show polyene antifungals are more effective than imidazoles or flucytosine. However, corticosteroids reduce antifungal efficacy, and corneal epithelium hinders polyene penetration.

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    Area of Science:

    • Mycology
    • Pharmacology
    • Ophthalmology

    Background:

    • Effective animal models are crucial for studying experimental fungal infections.
    • Topical antifungal therapy requires robust models to assess drug efficacy.
    • Rabbit models have been developed for evaluating antifungal treatments.

    Purpose of the Study:

    • To evaluate the efficacy of different antifungal agents in rabbit models.
    • To investigate the impact of corticosteroids on antifungal activity.
    • To assess the role of the corneal epithelium in antifungal drug penetration.

    Main Methods:

    • Development and application of two rabbit models for experimental fungal infections.
    • Comparison of polyenes, imidazoles, and flucytosine for topical antifungal therapy.

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  • Assessment of concomitant corticosteroid administration on antifungal efficacy.
  • Evaluation of corneal epithelial barrier function in polyene antibiotic penetration.

    • Main Results:

    • Polyenes demonstrated superior efficacy compared to imidazoles and flucytosine, with strain-dependent variations.
    • Concomitant corticosteroid administration negatively impacted in vivo antifungal activity.
    • The steroid effect was inversely related to the antifungal agent's efficacy.
    • The corneal epithelium presented a significant barrier to polyene antibiotic penetration.
    • A correlation between in vitro and in vivo efficacy was observed for amphotericin B against Candida albicans strains.

    Conclusions:

    • Rabbit models are valuable for studying topical antifungal therapy.
    • Polyenes are effective antifungals, but their efficacy is influenced by fungal strain and host factors.
    • Corticosteroids should be used cautiously with antifungals due to potential adverse effects.
    • The corneal epithelium is a critical factor in topical ocular antifungal treatment success.