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Prognostic and clinicopathological roles of circular RNA expression in chemoresistance in head and neck squamous cell

Sayan Kumar Das1, Sameer Khasbage2, Ashim Mishra3

  • 1Department of Pharmacology, Manipal Tata Medical College, Manipal Academy of Higher Education, Manipal, India.

Frontiers in Pharmacology
|April 3, 2025
PubMed
Summary

This study identified 13 circular RNAs (circRNAs) involved in head and neck squamous cell carcinoma (HNSCC) chemoresistance. These circRNAs could serve as potential biomarkers for predicting patient prognosis and chemotherapy response.

Keywords:
biomarkerchemoresistancecircular RNAhead and neck squamous cell carcinomamicroRNAsystematic review

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer with poor prognosis and high recurrence rates.
  • Chemoresistance significantly worsens outcomes in HNSCC patients.
  • Circular RNAs (circRNAs) have emerged as key regulators of cancer cell survival and chemoresistance.

Purpose of the Study:

  • To systematically identify circRNAs implicated in HNSCC chemoresistance.
  • To elucidate the mechanisms by which circRNAs influence chemoresistance in HNSCC.
  • To explore the potential of circRNAs as biomarkers for early detection of chemoresistance.

Main Methods:

  • A systematic literature review was conducted following PRISMA guidelines.
  • The review protocol was prospectively registered on PROSPERO (CRD42024532291).
  • Data from 13 identified studies were analyzed to identify relevant circRNAs and their functions.

Main Results:

  • Thirteen circRNAs were identified, with 11 found to be upregulated and 2 downregulated in HNSCC chemoresistance.
  • These circRNAs were found to modulate critical cellular processes including autophagy, apoptosis, drug efflux, epithelial-mesenchymal transition (EMT), tumor microenvironment, DNA damage, and malignant potential.
  • Specific examples include circPARD3, circPKD2, circAP1M2, circPGAM1, circ-ILF2, circANKS1B, circTPST2, circPUM1, circ_0001971, has_circ_0005033, circCRIM1, hsa_circ_0000190, and hg19_circ_0005033.

Conclusions:

  • Thirteen circRNAs have been identified as potentially playing significant roles in HNSCC chemoresistance.
  • These circRNAs represent promising candidates for developing novel biomarkers for HNSCC prognosis and predicting chemotherapy response.