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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

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Biodegradable dexamethasone polymer capsule for long-term release.

Avery Zheng¹, Thomas Waterkotte¹, Tilahun Debele¹

¹Department of Chemical & Environmental Engineering, College of Engineering & Applied Sciences.

The Korean Journal of Chemical Engineering

|April 3, 2025

Summary

Biodegradable polymer capsules provide sustained local delivery of dexamethasone (Dex) for inflammatory diseases. Polymer hydrophobicity controls Dex release rate, with more hydrophobic polymers showing slower drug release and effective IL-6 suppression in vitro.

Keywords:

Biodegradable Dexamethasone Injectable Implant Long-term Drug Delivery PCL PLA PLGA

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Area of Science:

Biomaterials Science
Drug Delivery Systems
Polymer Chemistry

Background:

Inflammatory diseases require effective local drug delivery.
Sustained-release implants offer therapeutic advantages over conventional methods.
Dexamethasone (Dex) is a potent anti-inflammatory corticosteroid.

Purpose of the Study:

To develop and characterize sustained-release dexamethasone (Dex) capsule implants using various biodegradable polymers.
To investigate the influence of polymer properties on Dex release kinetics.
To evaluate the in vitro therapeutic efficacy and toxicity of the Dex implants.

Main Methods:

Fabrication of Dex implants using polycaprolactone (PCL), poly(lactic acid) (PLA), and two ratios of poly(lactic-co-glycolic acid) (PLGA).
Drug release studies fitting data to a cylindrical reservoir first-order kinetics model.
In vitro efficacy testing using TNF-α stimulated human umbilical vein endothelial cells (HUVECs) to measure IL-6 levels.

Main Results:

Drug release rates varied significantly among the polymers, with 50:50 PLGA exhibiting the fastest release and PCL the slowest.
Drug release kinetics were strongly correlated with polymer hydrophobicity; more hydrophobic polymers resulted in slower release of the hydrophilic drug.
Dex implants effectively suppressed IL-6 levels in HUVECs with minimal toxicity compared to free Dex.

Conclusions:

The release rate of dexamethasone from biodegradable implants is predictable and controllable based on polymer hydrophobicity.
Sustained-release Dex implants demonstrate significant potential for localized treatment of inflammatory conditions.
This study provides a foundation for designing optimized polymer-drug delivery systems for inflammatory disease management.