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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Related Experiment Video

Updated: Jul 9, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Size-transformable nanotherapeutics for cancer therapy.

Teng Ma1, Tuyen Ba Tran1, Ethan Lin1

  • 1Skaggs Pharmaceutical Sciences Center, Department of Pharmacology & Toxicology, R. Ken Coit College of Pharmacy, the University of Arizona, Tucson 85721, AZ, USA.

Acta Pharmaceutica Sinica. B
|April 3, 2025
PubMed
Summary

Size-transformable nanodrugs offer a solution to the dilemma of choosing optimal nanomedicine sizes. These adaptable nanoparticles combine the benefits of both small and large nanodrugs for enhanced therapeutic applications.

Keywords:
Cancer therapyDrug deliverySelf-assembleSize-transformationSmart nanomedicine

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Nanodrug size critically impacts chemical, physical, and biological interactions.
  • Optimal nanomedicine size presents a challenge, as small and large nanoparticles offer distinct therapeutic advantages.
  • Current nanomedicine approaches face a dilemma in selecting the ideal nanoparticle size for disease treatment.

Purpose of the Study:

  • To review strategies for creating size-transformable nanosystems.
  • To highlight nanotherapeutic applications, particularly in cancer therapy.
  • To inspire further development of size-transformable nanomedicines for diverse diseases.

Main Methods:

  • Review of existing literature on nanodrug design and fabrication.
  • Analysis of strategies for achieving size transformation in nanoparticles.
  • Focus on nanomedicines with adaptable size characteristics.

Main Results:

  • Size-transformable nanodrugs can integrate benefits of both small and large nanoparticles.
  • Various construction strategies for adaptable nanosystems are summarized.
  • Recent advancements in size-transformable nanomedicines for cancer therapy are highlighted.

Conclusions:

  • Size-transformable nanodrugs present a promising solution to nanomedicine size selection challenges.
  • Further research into fabrication toolboxes is encouraged for improved disease intervention.
  • These adaptable nanomedicines hold potential for enhanced treatment of various human diseases.