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Related Concept Videos

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo
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Dendritic cells immunotargeted therapy for atherosclerosis.

Zhaohui Li1, Yanyan Yang2, Jinbao Zong3

  • 1Department of Vascular Surgery, the Affiliated Hospital of Qingdao University, Qingdao, 266400, China.

Acta Pharmaceutica Sinica. B
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PubMed
Summary

Dendritic cells are key immune cells in atherosclerosis, influencing inflammation and immune responses. Dendritic cell-based therapies, including vaccines and nanodelivery, show promise for treating this chronic inflammatory disease.

Keywords:
AtherosclerosisDeliveryDendritic cellImmunotherapyInflammation

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Area of Science:

  • Immunology
  • Cardiovascular Research
  • Inflammation Biology

Background:

  • Atherosclerosis is a chronic inflammatory disease driven by immune and inflammatory processes.
  • Dendritic cells (DCs) are crucial antigen-presenting cells involved in initiating immune responses and maintaining homeostasis.
  • DCs are found in healthy arteries and accumulate in atherosclerotic plaques, highlighting their role in the disease.

Purpose of the Study:

  • To review the functions and mechanisms of dendritic cells and their subsets in modulating atherosclerotic inflammation.
  • To explore the potential of dendritic cell-centric immunotherapies for atherosclerosis treatment.
  • To discuss challenges and future directions in dendritic cell immunotherapy for atherosclerosis.

Main Methods:

  • Literature review focusing on dendritic cell function in atherosclerosis.
  • Analysis of current immunotherapeutic strategies and vaccination protocols.
  • Examination of nanotechnological drug delivery platforms in combination with DC-based therapies.

Main Results:

  • Dendritic cells significantly influence the immune and inflammatory milieu of atherosclerotic plaques.
  • DC subsets play distinct roles in the initiation and progression of atherosclerosis.
  • DC-based immunotherapies, including vaccines and nanodelivery systems, demonstrate therapeutic potential.

Conclusions:

  • Dendritic cells are critical regulators of immune responses in atherosclerosis.
  • DC-based immunotherapies offer a promising avenue for managing atherosclerosis.
  • Further research into DC immunotherapy, combined with advanced delivery systems, is warranted to overcome challenges and optimize treatment outcomes.