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Plasma levels of small HDL particles are associated with coronary atherosclerosis progression in adults with diabetes

  • 0Medical Sciences Post-graduation Program, University of Brasília, Brasília, DF, Brazil.
The Journal of Clinical Endocrinology and Metabolism +

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April 3, 2025

|

April 3, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Small HDL particles (HDLp1) predict coronary artery calcium progression in type 2 diabetes mellitus (T2DM). Higher HDLp1 levels significantly increase the risk of atherosclerosis, improving cardiovascular risk assessment in T2DM patients.

Area Of Science

  • Cardiovascular Medicine
  • Metabolic Disorders
  • Biomarker Discovery

Background

  • Type 2 diabetes mellitus (T2DM) accelerates coronary atherosclerosis, but risk is variable.
  • Insulin resistance drives metabolic disturbances that impact atherogenesis.
  • Improved cardiovascular risk prediction biomarkers are needed for T2DM patients.

Purpose Of The Study

  • To investigate the link between small HDL particle concentration and coronary artery calcium (CAC) progression in T2DM.
  • To assess if small HDL particles improve risk stratification for coronary atherosclerosis.

Main Methods

  • Analysis of 4,331 participants from the ELSA-Brasil cohort.
  • Comparison of CAC incidence/progression between T2DM and non-diabetic individuals.
  • Subgroup analysis of 461 T2DM non-statin users for small HDL particles (<8nm, HDLp1) and CAC outcomes.

Main Results

  • T2DM patients exhibited higher CAC incidence/progression rates.
  • In T2DM subgroup, higher HDLp1 concentrations (3rd tertile) were linked to a 140% increased likelihood of CAC incidence/progression.
  • HDLp1 inclusion significantly improved CAC risk classification (NRI 13.6%).

Conclusions

  • Small HDL particle (HDLp1) concentration is a significant predictor of CAC incidence/progression in T2DM.
  • HDLp1 may enhance risk discrimination for coronary atherosclerosis progression in individuals with T2DM.

Keywords:

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