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Updated: May 16, 2025

The Identification of Sea Lamprey Pheromones Using Bioassay-Guided Fractionation
Published on: July 17, 2018
Functional Characterization and Small Molecule Drug Screening of Sex Pheromone Receptors in Ectropis obliqua
Jing Chen1, Fengyuan Wei1, Quan Li1
1College of Forestry and Biotechnology, Zhejiang A & F University, Hangzhou 311300, Zhejiang, China.
Abstract:
Ectropis obliqua (Lepidoptera: Geometridae) is a major pest of tea plants in China. Sex pheromone traps are effective for monitoring and controlling its population. However, the specific mechanisms of sex pheromone recognition in this pest remain unclear. Fifty-seven candidate odorant receptors were identified using antennal transcriptome analysis, including two potential pheromone receptors (EoblOR17 and EoblOR45). Expression profiles indicated that EoblOR17 and EoblOR45 were highly expressed in the males. Among them, EoblOR17 was identified in response to the primary pheromone components of E. obliqua, Z3,epo6,Z9-18:H and Z3,Z6,Z9-18:H. The in vivo function of EoblOR17 was confirmed using RNA interference (RNAi) analysis. A small molecule (T7392) targeting EoblOR17 significantly reduced the mating rate of E. obliqua. Our findings provide a better understanding of the mechanisms of sex pheromone recognition in E. obliqua and provide a class of potential compounds to control this pest.
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