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Updated: May 5, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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Clinical Outcomes Amongst Patients Infected With Candida Auris: A Single-Center Study.

Sara Al Jabi1,2, Rania El-Lababidi1, Emna Abidi1

  • 1Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.

Mycoses
|April 3, 2025
PubMed
Summary
This summary is machine-generated.

Outcomes for Candida auris infections show clinical cure depends on mycologic cure and ICU stay length. High mortality rates underscore the need for effective Candida auris treatment strategies.

Keywords:
C. aurisfungal infectionmanagement

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Area of Science:

  • Infectious Diseases
  • Clinical Microbiology

Background:

  • Candida auris poses a therapeutic challenge due to diagnostic difficulties and lack of defined susceptibility breakpoints.
  • Misidentification and suboptimal therapy contribute to poor treatment outcomes for C. auris infections.

Purpose of the Study:

  • To assess the clinical outcomes of Candida auris infections at a single institution.
  • To identify predictors of clinical cure in patients with C. auris infections.

Main Methods:

  • Retrospective observational study of confirmed C. auris cases from January 2019 to June 2022.
  • Primary endpoint: clinical outcomes. Secondary endpoints: mycologic cure, infection recurrence (30/90 days), and 30-day mortality.
  • Descriptive statistics and multivariable logistic regression were used for data analysis.

Main Results:

  • Fifty-six patients evaluated; 62.7% had candidemia. Clinical cure was 57%, mycologic cure 84.4%.
  • Recurrence rates were 28.6% at 30 days and 12.7% at 90 days. 30-day all-cause mortality was 28.6%.
  • Independent predictors of clinical cure included mycologic cure (OR 6.96), shorter ICU stay (OR 0.132), and lower baseline CRP (OR 0.990).

Conclusions:

  • Clinical cure for invasive C. auris infections is linked to mycologic cure, ICU length of stay, and baseline CRP.
  • Most isolates showed resistance to fluconazole and amphotericin B; rare pan-resistance to caspofungin was observed.
  • Further multi-center studies are required to validate these findings and inform treatment guidelines for C. auris.