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Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
Successful sequential application of CAR T-cell-therapies in relapsed refractory multiple myeloma
Paul Mobascher1, Monika Engelhardt1, Ralph Wäsch2
1Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, Medical Center - University of Freiburg, University of Freiburg, Hugstetterstrasse 55, 79106, Freiburg, Germany.
Abstract:
We here report on a patient with relapsed-refractory multiple myeloma (RRMM) who received chimeric antigen receptor (CAR) T-cells (Ciltacabtagene Autoleucel, cilta-cel, Carvykti®) after achieving a partial but not durable remission with Idecabtagene Vicleucel (ide-cel, Abecma®). Both CAR T-cells target the B-cell maturation antigen (BCMA) and their sequential use is as yet rare, thus data on safety and efficacy of their sequential employment are precious and relevant for the myeloma commmunity.

