Related Experiment Video

Updated: May 16, 2025

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
09:31

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe

Published on: September 17, 2021

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Oxidative stress as a catalyst in prostate cancer progression: unraveling molecular mechanisms and exploring

Yawen Song1, Zheng Hou2, Longting Zhu3

  • 1Department of Urology, Xijing Hospital of Air Force Military Medical University, Xi'an, China.

Discover Oncology
|April 3, 2025
PubMed

Insights

Reactive oxygen species (ROS) drive prostate cancer progression and treatment resistance. Understanding ROS generation and their role in the tumor microenvironment is key to developing new antioxidant therapies for prostate cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Prostate cancer incidence and mortality are rising globally.
  • Androgen deprivation therapy (ADT) efficacy is limited by treatment resistance, especially in metastatic disease.
  • Reactive oxygen species (ROS) induce oxidative stress, impacting cellular functions and promoting cancer progression.

Purpose of the Study:

  • To systematically review ROS generation pathways in prostate cancer.
  • To explore the interaction between ROS and androgen receptor signaling.
  • To investigate the influence of external factors like obesity and aging on ROS production.

Main Methods:

  • Systematic literature review of ROS generation in prostate cancer.
  • Analysis of ROS interaction with androgen receptor signaling pathways.
  • Examination of ROS-mediated mechanisms including tumor microenvironment modulation, unfolded protein response (UPR) activation, and miRNA regulation.

Main Results:

  • Elevated ROS levels promote prostate cancer proliferation, invasion, angiogenesis, and extracellular matrix remodeling.
  • ROS contribute to treatment resistance in prostate cancer.
  • External factors like obesity and aging exacerbate ROS production, fueling cancer progression.

Conclusions:

  • ROS play a multifaceted role in driving prostate cancer progression and malignancy.
  • Targeted antioxidant strategies informed by ROS-mediated mechanisms hold promise for novel prostate cancer therapeutics.
  • Further research into ROS pathways could overcome ADT resistance in prostate cancer.
Keywords:
AntioxidantsProstate cancerROS

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