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Bone alterations in head and neck pleomorphic adenoma: Scoping review
C De Vriese1,2,3, E Van Hul4, D Loose5
1Department of Otolaryngology, Head and Neck Surgery, General Hospital Vitaz, Sint-Niklaas, Belgium. Casper.DeVriese@ugent.be.
Oral Radiology
|April 3, 2025
Summary
Pleomorphic adenomas can cause bone destruction in the head and neck, but this is rare. Larger or long-standing tumors increase this risk, though malignancy is still more likely with bone destruction.
Area of Science:
- Oncology
- Oral and Maxillofacial Surgery
- Pathology
Background:
- Bone destruction adjacent to salivary gland tumors often suggests malignancy.
- Pleomorphic adenoma is the most common salivary gland neoplasm.
- Understanding bone changes associated with pleomorphic adenoma is crucial for diagnosis.
Purpose of the Study:
- To explore bone changes associated with head and neck pleomorphic adenoma.
- To identify risk factors for bone destruction in pleomorphic adenoma cases.
Main Methods:
- A scoping review was conducted following PRISMA-ScR guidelines.
- Searched PubMed, Scopus, and Scholar for articles on bone alterations in head and neck pleomorphic adenoma.
- Included histopathologically confirmed cases, extracting data on tumor characteristics and bone erosion.
Main Results:
- 145 pleomorphic adenomas with adjacent bone alterations were identified.
- Expansile bone changes like cortex erosion (61.4%) and scalloping (31.0%) were most common.
- Extensive bone destruction occurred in 11 cases; tumor size and symptom duration were significant risk factors for aggressive destruction.
Conclusions:
- While bone erosion and scalloping are typical, larger or long-standing pleomorphic adenomas can cause extensive bone destruction without malignancy.
- Bone destruction in pleomorphic adenoma is rare and warrants careful evaluation, as it can indicate malignancy.
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