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Updated: May 16, 2025

On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis

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Published on: May 31, 2020

Chromosome 1p Loss and 1q Gain for Grading of Meningioma.

Alexander P Landry^1,2,3, Justin Z Wang^1,2,3, Vikas Patil^1,3

¹MacFeeters Hamilton Neuro-Oncology Program, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, Ontario, Canada.

|April 3, 2025

Summary

Chromosomal copy number alterations, specifically chromosome 1p loss and 1q gain, can significantly refine meningioma grading. These genetic markers improve the prediction of progression-free survival and aid in updating the World Health Organization (WHO) classification of central nervous system (CNS) tumors.

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A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

Published on: March 7, 2017

Area of Science:

Neuro-oncology
Genetics
Cancer Research

Background:

The 2021 World Health Organization (WHO) classification for central nervous system (CNS) tumors introduced rare molecular features for meningioma grading.
Previous research suggested incorporating chromosomal copy number alterations (CNAs) to enhance meningioma grading systems.

Purpose of the Study:

To identify specific chromosomal copy number alterations (CNAs) that can improve the current CNS WHO grading of meningioma.
To correlate CNAs with progression-free survival (PFS) to discover novel outcome biomarkers.

Main Methods:

A multi-institutional cohort study involving surgically treated meningioma patients.
Analysis of chromosomal copy number alterations and their correlation with progression-free survival (PFS) using Cox regression.
Data collected from 2016 and analyzed between January and September 2024.

Main Results:

Loss of chromosome 1p in WHO grade 1 meningiomas was associated with significantly worse PFS, comparable to WHO grade 2 tumors.
Combined loss of chromosome 1p and gain of chromosome 1q correlated with outcomes similar to WHO grade 3 tumors, irrespective of initial grade.
A total of 1964 meningioma patients were assessed.

Conclusions:

Cytogenetic profiling, particularly chromosome 1p loss and 1q gain, should be considered for future CNS WHO grading iterations.
Chromosome 1p loss should be a criterion for CNS WHO grade 2, and 1q gain for CNS WHO grade 3 meningiomas.
These findings underscore the prognostic value of specific CNAs in meningioma.