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Immune repertoire profiling uncovers pervasive T cell clonal expansions in benign prostatic hyperplasia

Anna S Pollack1, Christian A Kunder1, Chandler C Ho1

  • 1Department of Pathology, Stanford University School of Medicine, Stanford, United States of America.

The Journal of Clinical Investigation
|April 3, 2025
PubMed
Abstract

Keywords:
ImmunologyInflammationProstate cancerReproductive biologyT cellsUrology

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T Cell Activation and Clonal Selection01:22

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...