Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-objective optimization in population pharmacokinetic model selection and optimization: application of NSGA-II in pyDarwin.

Journal of pharmacokinetics and pharmacodynamics·2026
Same author

Virtual Bioequivalence Assessment of Long-Acting Injectable Suspensions Using PBPK Modeling: Part 2. Type I Error and Safe Space Analyses.

The AAPS journal·2026
Same author

Virtual Bioequivalence Assessment of Long-acting Injectable Suspensions Using PBPK Modeling: Part 1. Impact of particle Size on Formulation Variability.

The AAPS journal·2026
Same author

Pirana and Integrated PMX Tools, a Workbench for NONMEM, NLME, pyDarwin, and RsNLME.

CPT: pharmacometrics & systems pharmacology·2025
Same author

Mechanistic Model for Drug Release from PLGA-Based Biodegradable Implants for <i>In Vitro</i> Release Testing: Development and Validation.

ACS applied bio materials·2024
Same author

A guide to developing population files for physiologically-based pharmacokinetic modeling in the Simcyp Simulator.

CPT: pharmacometrics & systems pharmacology·2024
Same journal

Development and Use of a Population Pharmacokinetic Model for Characterizing the Pharmacokinetics of Vonoprazan in Pediatric Patients.

CPT: pharmacometrics & systems pharmacology·2026
Same journal

A Narrative Review of Artificial Intelligence for Drug Repurposing: Lessons From COVID-19 and Oncology (2020-2025).

CPT: pharmacometrics & systems pharmacology·2026
Same journal

Butorphanol Pharmacokinetics Across Species: Meta-Analysis Integrating Allometric Scaling and Minimal Physiologically Based Pharmacokinetic Modeling.

CPT: pharmacometrics & systems pharmacology·2026
Same journal

Accelerating Subcutaneous Drug Development: A Mechanistic Absorption Model for the Open Systems Pharmacology Framework.

CPT: pharmacometrics & systems pharmacology·2026
Same journal

Automated Pharmacometric Model Development by Leveraging Low-Dimensional Neural ODEs and LASSO Regression.

CPT: pharmacometrics & systems pharmacology·2026
Same journal

Population Pharmacokinetics and Pharmacodynamics of Paracetamol in Malaysian Patients With Plasmodium knowlesi Malaria.

CPT: pharmacometrics & systems pharmacology·2026
See all related articles

Related Experiment Video

Updated: May 12, 2026

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology
08:54

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Published on: April 18, 2018

9.7K

Using the Simcyp R Package for PBPK Simulation Workflows With the Simcyp Simulator.

Anthonia M Onasanwo1, Naresh Mittapelly1, Laura Shireman1

  • 1Certara Predictive Technologies, Sheffield, UK.

CPT: Pharmacometrics & Systems Pharmacology
|April 3, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces an R package to automate Physiologically Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) modeling with the Simcyp Simulator. This integration streamlines complex drug development simulations, reducing analysis time from days to hours.

Keywords:
PBPK modelingR statistical softwaresimulation workflow

More Related Videos

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
09:17

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

3.0K
Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

2.0K

Related Experiment Videos

Last Updated: May 12, 2026

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology
08:54

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Published on: April 18, 2018

9.7K
Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
09:17

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

3.0K
Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

2.0K

Area of Science:

  • Pharmacokinetics and Pharmacodynamics
  • Computational Biology
  • Drug Development

Background:

  • Physiologically Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) modeling is crucial for understanding drug behavior in vivo.
  • The Simcyp Simulator is a powerful commercial tool for PBPK/PD simulations.
  • Integrating R with PBPK/PD software can enhance efficiency and analytical capabilities.

Purpose of the Study:

  • To describe an R package (version 23.0.64) that interfaces with the Simcyp Simulator.
  • To demonstrate automated workflows for PBPK/PD model development and verification.
  • To showcase accelerated simulation execution, analysis, and visualization.

Main Methods:

  • Development of an R package to control Simcyp Simulator inputs and process outputs.
  • Implementation of automated workflows for model verification and virtual bioequivalence assessment.
  • Utilized R for scripting, automation, statistical analysis, and result visualization.

Main Results:

  • Successful integration of R with the Simcyp Simulator for automated PBPK/PD modeling.
  • Demonstrated verification of a drug-drug interaction model for Atazanavir.
  • Showcased virtual bioequivalence assessment for paliperidone palmitate long-acting injectable suspensions.
  • Reduced simulation and analysis time significantly, from days to hours.

Conclusions:

  • The R package significantly enhances the efficiency of PBPK/PD modeling using the Simcyp Simulator.
  • Automated workflows facilitate faster and more robust drug development and clinical research.
  • This approach accelerates the assessment of drug interactions and bioequivalence.