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Transvaginal Detrusor Nerve Radiofrequency Ablation for Overactive Bladder
Gamal Ghoniem1, Mickey Karram2, Mauricio Wagner3
1University of California Irvine Medical Center, Irvine, CA.
Urogynecology (Philadelphia, Pa.)
|April 3, 2025
Summary
Transvaginal radiofrequency ablation effectively improved overactive bladder (OAB) symptoms, including urgency incontinence and frequency. This minimally invasive treatment demonstrated significant efficacy and safety in female patients with OAB.
Area of Science:
- Urology
- Gynecology
- Minimally Invasive Procedures
Background:
- Autonomic nerves below the proximal urethra and trigone influence bladder function.
- Radiofrequency (RF) energy shows potential for ablating/modulating these nerves in overactive bladder (OAB) patients.
Purpose of the Study:
- To assess the safety and efficacy of transvaginal RF energy delivery using a microneedling device for OAB treatment.
- To evaluate improvements in OAB symptoms and quality of life.
Main Methods:
- Female patients with OAB underwent transvaginal detrusor nerve RF ablation to a depth of 7 mm.
- Outcomes included changes in incontinence episodes, urinary frequency, and validated quality-of-life questionnaires (IIQ-7, UDI-6, PPBC).
- Safety was monitored via pain assessment and adverse event reporting.
Main Results:
- Statistically significant improvements were observed in urgency incontinence episodes, urinary frequency, and quality-of-life scores (IIQ-7, UDI-6, PPBC) at 3 months.
- No adverse events were reported during the study period.
- Significant ANOVA testing (P < 0.001) confirmed the efficacy of the treatment.
Conclusions:
- Transvaginal detrusor nerve RF ablation is a safe and effective treatment for overactive bladder.
- The procedure leads to statistically significant improvements across multiple outcome metrics for OAB patients.
